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Table 1 Baseline clinical characteristics between LDL-C target achievers and non-achievers

From: Lower body mass index is associated with the achievement of target LDL in patients using PCSK9 inhibitors in Taiwan

 

Total N = 211

LDL-C target non-achiever N = 91

LDL-C target achiever N = 120

P value

Age (yrs) (Mean ± SD)

57.2 ± 13.1

56.1 ± 15.0

58.0 ± 11.5

0.429

[Median (IQR)]

59.0 (48.0, 66.0)

58.0 (47.0, 69.0)

59.0 (50.0, 66.0)

 

Sex (male)

152

(72.0)

65

(71.4)

87

(72.5)

0.987

BMI (kg/m2) (Mean ± SD)

26.4 ± 4.1

27.4 ± 4.5

25.8 ± 3.7

0.028

[Median (IQR)]

26.2 (23.8, 28.4)

27.0 (24.6, 29.4)

25.4 (23.2, 28.2)

 

Hypertension

126

(59.7)

51

(56.0)

75

(62.5)

0.421

Diabetes mellitus

73

(34.6)

35

(38.5)

38

(31.7)

0.378

Smoker

54

(25.6)

21

(23.1)

33

(27.5)

0.569

HFrEF

18

(8.5)

7

(7.7)

11

(9.2)

0.896

Coronary artery disease

126

(59.7)

48

(52.8)

78

(65.0)

0.098

Myocardial infarction

72

(34.1)

23

(25.3)

49

(40.8)

0.027

Peripheral artery disease

10

(4.7)

5

(5.5)

5

(4.2)

0.749

Ischemic stroke or TIA

13

(6.2)

5

(5.5)

8

(6.7)

0.951

CKD without dialysis

25

(11.8)

9

(9.9)

16

(13.3)

0.581

ESRD under dialysis

4

(1.9)

1

(1.1)

3

(2.5)

0.636

COPD

5

(2.4)

3

(3.3)

2

(1.7)

0.654

Liver cirrhosis

2

(1.0)

0

(0.0)

2

(1.7)

0.507

Cancer

11

(5.2)

2

(2.2)

9

(7.5)

0.120

Anti-platelet drugs

181

(85.8)

72

(79.1)

109

(90.8)

0.027

Beta blocker

102

(48.3)

40

(44.0)

62

(51.7)

0.332

RAS inhibitor

91

(43.1)

32

(35.2)

59

(49.2)

0.058

Non HIS

77

(36.5)

34

(37.4)

43

(35.8)

0.933

HIS

14

(6.6)

6

(6.6)

8

(6.7)

1.000

Non HIS + Ezetimibe

48

(22.8)

26

(28.6)

22

(18.3)

0.112

HIS + Ezetimibe

72

(34.1)

25

(27.5)

47

(39.2)

0.104

Alirocumab

155

(73.5)

73

(80.2)

82

(68.3)

0.075

Evolocumab

56

(26.5)

18

(19.8)

38

(31.7)

0.075

  1. Continuous variables were analyzed using the student t or Mann–Whitney U test, while categorical variables were assessed using the chi-square test or Fisher’s exact test
  2. BMI: body mass index; CKD: chronic kidney disease; COPD: chronic obstructive pulmonary disease; ESRD: end stage renal disease; IQR: interquartile range; HFrEF: heart failure with reduced ejection fraction; HIS: high intensity statins; LDL-C: low-density lipoprotein cholesterol; RAS inhibitor: renin-angiotensin system inhibitors; SD: standard deviation; TIA: transient ischemic attack